Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus

Hypervariable region 1 (HVR1) of envelope protein 2 (E2) of hepatitis C virus (HCV) serves important yet undefined roles in the viral life cycle. We previously showed that the viability of HVR1-deleted JFH1-based recombinants with Core-NS2 of H77 (H77(ΔHVR1), genotype 1a) and S52 (S52(ΔHVR1), genoty...

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Autors principals: Prentoe, Jannick, Serre, Stéphanie B. N., Ramirez, Santseharay, Nicosia, Alfredo, Gottwein, Judith M., Bukh, Jens
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911595/
https://ncbi.nlm.nih.gov/pubmed/24257605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02017-13
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