Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle

Hepatitis C virus (HCV) NS3 protease inhibitors (PIs) are important components of novel HCV therapy regimens. Studies of PI resistance initially focused on genotype 1. Therefore, knowledge about the determinants of PI resistance for the highly prevalent genotypes 2 to 6 remains limited. Using Huh7.5...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Serre, Stéphanie B. N., Jensen, Sanne B., Ghanem, Lubna, Humes, Daryl G., Ramirez, Santseharay, Li, Yi-Ping, Krarup, Henrik, Bukh, Jens, Gottwein, Judith M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879388/
https://ncbi.nlm.nih.gov/pubmed/27021330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02929-15
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