Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

BACKGROUND: Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism. Contribution of amino acid metabolic regulation in the disease remains understudied. METHODS AND RESULTS: Transcriptomic and m...

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Bibliografske podrobnosti
izdano v:Circulation
Main Authors: Sun, Haipeng, Olson, Kristine C., Gao, Chen, Prosdocimo, Domenick A., Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D., Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S., Wynn, R. Max, Newgard, Christopher B., Cai, Hua, Xiao, Xinshu, Chuang, David T., Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K., Wang, Yibin
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879058/
https://ncbi.nlm.nih.gov/pubmed/27059949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020226
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