Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

BACKGROUND: Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism. Contribution of amino acid metabolic regulation in the disease remains understudied. METHODS AND RESULTS: Transcriptomic and m...

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Publicado no:Circulation
Main Authors: Sun, Haipeng, Olson, Kristine C., Gao, Chen, Prosdocimo, Domenick A., Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D., Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S., Wynn, R. Max, Newgard, Christopher B., Cai, Hua, Xiao, Xinshu, Chuang, David T., Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K., Wang, Yibin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879058/
https://ncbi.nlm.nih.gov/pubmed/27059949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020226
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