Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

BACKGROUND: Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism. Contribution of amino acid metabolic regulation in the disease remains understudied. METHODS AND RESULTS: Transcriptomic and m...

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Foilsithe in:Circulation
Main Authors: Sun, Haipeng, Olson, Kristine C., Gao, Chen, Prosdocimo, Domenick A., Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D., Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S., Wynn, R. Max, Newgard, Christopher B., Cai, Hua, Xiao, Xinshu, Chuang, David T., Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K., Wang, Yibin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879058/
https://ncbi.nlm.nih.gov/pubmed/27059949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020226
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