Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

BACKGROUND: Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism. Contribution of amino acid metabolic regulation in the disease remains understudied. METHODS AND RESULTS: Transcriptomic and m...

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Publicado en:Circulation
Autores principales: Sun, Haipeng, Olson, Kristine C., Gao, Chen, Prosdocimo, Domenick A., Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D., Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S., Wynn, R. Max, Newgard, Christopher B., Cai, Hua, Xiao, Xinshu, Chuang, David T., Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K., Wang, Yibin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879058/
https://ncbi.nlm.nih.gov/pubmed/27059949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020226
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