Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

The COP9-Signalosome (CSN) regulates cullin–RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine structural and kinetic analyses to identify mechanisms that contribute to CSN activatio...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Mosadeghi, Ruzbeh, Reichermeier, Kurt M, Winkler, Martin, Schreiber, Anne, Reitsma, Justin M, Zhang, Yaru, Stengel, Florian, Cao, Junyue, Kim, Minsoo, Sweredoski, Michael J, Hess, Sonja, Leitner, Alexander, Aebersold, Ruedi, Peter, Matthias, Deshaies, Raymond J, Enchev, Radoslav I
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878873/
https://ncbi.nlm.nih.gov/pubmed/27031283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12102
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