Carregant...

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism

COP9 signalosome (CSN) mediates deconjugation of the ubiquitin-like protein Nedd8 from the cullin subunits of SCF and other cullin-RING ubiquitin ligases (CRLs). This process is essential to maintain the proper activity of CRLs in cells. Here, we report a detailed kinetic characterization of CSN-med...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Emberley, Ethan D., Mosadeghi, Ruzbeh, Deshaies, Raymond J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436198/
https://ncbi.nlm.nih.gov/pubmed/22767593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352484
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!