Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism

COP9 signalosome (CSN) mediates deconjugation of the ubiquitin-like protein Nedd8 from the cullin subunits of SCF and other cullin-RING ubiquitin ligases (CRLs). This process is essential to maintain the proper activity of CRLs in cells. Here, we report a detailed kinetic characterization of CSN-med...

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Bibliographic Details
Main Authors: Emberley, Ethan D., Mosadeghi, Ruzbeh, Deshaies, Raymond J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436198/
https://ncbi.nlm.nih.gov/pubmed/22767593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352484
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