Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

The COP9-Signalosome (CSN) regulates cullin–RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine structural and kinetic analyses to identify mechanisms that contribute to CSN activatio...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Mosadeghi, Ruzbeh, Reichermeier, Kurt M, Winkler, Martin, Schreiber, Anne, Reitsma, Justin M, Zhang, Yaru, Stengel, Florian, Cao, Junyue, Kim, Minsoo, Sweredoski, Michael J, Hess, Sonja, Leitner, Alexander, Aebersold, Ruedi, Peter, Matthias, Deshaies, Raymond J, Enchev, Radoslav I
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Biochemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878873/
https://ncbi.nlm.nih.gov/pubmed/27031283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12102
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