T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.
Why T cells develop autoimmune reactivity to some antigens and tolerance to others is unknown. Various mechanisms can provide for T-cell tolerance. These include deletion in the thymus, exhaustive differentiation in the periphery, T-cell receptor and coreceptor downregulation, and anergy. Which mech...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48788/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1532662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2985 |
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