Molecular mechanism of APC/C activation by mitotic phosphorylation

In eukaryotes, the anaphase-promoting complex/cyclosome (APC/C) regulates the ubiquitin-dependent proteolysis of specific cell cycle proteins to coordinate chromosome segregation in mitosis and entry into G1 (refs 1,2). The APC/C’s catalytic activity and ability to specify the destruction of particu...

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發表在:Nature
Main Authors: Zhang, Suyang, Chang, Leifu, Alfieri, Claudio, Zhang, Ziguo, Yang, Jing, Maslen, Sarah, Skehel, Mark, Barford, David
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878669/
https://ncbi.nlm.nih.gov/pubmed/27120157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17973
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