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Atomic structure of the APC/C and its mechanism of protein ubiquitination

The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by coactivator subunits, phosphorylation, the mitotic checkpoint complex, and interphase inhibitor Emi1 ensures the correct order and timing of distin...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Chang, Leifu, Zhang, Ziguo, Yang, Jing, McLaughlin, Stephen H., Barford, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608048/
https://ncbi.nlm.nih.gov/pubmed/26083744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14471
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