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Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs
The ribosome uses initial and proofreading selection of aminoacyl-tRNAs for accurate protein synthesis. Anomalously high initial misreading in vitro of near-cognate codons by tRNA(His) and tRNA(Glu) suggested potential error hotspots in protein synthesis, but in vivo data suggested their partial neu...
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| Publié dans: | RNA |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4878615/ https://ncbi.nlm.nih.gov/pubmed/27090284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055632.115 |
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