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Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase

We suggest a novel two-step proofreading mechanism with two sequential rounds of proofreading selection in mRNA transcription. It is based on the previous experimental observations that the proofreading RNA polymerase cleaves off transcript fragments of at least 2 nt and that transcript elongation a...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mellenius, Harriet, Ehrenberg, Måns
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714138/
https://ncbi.nlm.nih.gov/pubmed/29036494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx849
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