Structural alterations of the epidermal growth factor receptor gene in human gliomas.

The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas, and the amplified genes are frequently rearranged. We have characterized the genetic alterations associated with these rearrangements in five malignant gliomas. In one tumor the rearrangement resulted in the d...

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Detalhes bibliográficos
Main Authors: Wong, A J, Ruppert, J M, Bigner, S H, Grzeschik, C H, Humphrey, P A, Bigner, D S, Vogelstein, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC48784/
https://ncbi.nlm.nih.gov/pubmed/1557402
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