Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling

Hypoxia induces a complex circuit of gene expression that drives tumor progression and increases drug resistance. Defining these changes allows for an understanding of how hypoxia alters tumor biology and informs design of lead therapeutics. We probed the role of microRNA-544 (miR-544), which silenc...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Haga, Christopher L., Velagapudi, Sai Pradeep, Strivelli, Jacqueline R., Yang, Wang-Yong, Disney, Matthew D., Phinney, Donald G.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876818/
https://ncbi.nlm.nih.gov/pubmed/26181590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00265
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