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Hypoxia and gerosuppression: The mTOR saga continues

Growth-promoting and nutrient/mitogen-sensing pathways such as mTOR convert p21- and p16-induced arrest into senescence (geroconversion). We have recently demonstrated that hypoxia, especially near-anoxia, suppresses geroconversion. This gerosuppressive effect of hypoxia correlated with inhibition o...

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Sonraí Bibleagrafaíochta
Main Authors: Leontieva, Olga V., Blagosklonny, Mikhail V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507487/
https://ncbi.nlm.nih.gov/pubmed/22987149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21908
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