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The CD4 and CD3δε cytosolic juxtamembrane regions are proximal within a compact TCR-CD3-pMHC-CD4 macro-complex
T-cell receptors (TCRs) relay information about peptides embedded within major histocompatibility complex molecules (pMHC) to the immunoreceptor tyrosine-based activation motifs (ITAMs) of the associated CD3γε, CD3δε, and CD3ζζ signaling modules. CD4 then recruits the Src kinase, Lck, to the TCR-CD3...
Guardat en:
| Publicat a: | J Immunol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4875830/ https://ncbi.nlm.nih.gov/pubmed/27183595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502110 |
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