A mechanical switch couples T cell receptor triggering to the cytoplasmic juxtamembrane regions of CD3ζζ

The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across the cell membrane for conversion to chemical signals remains unresolved. We hypothesized that TCR engagement triggers a change in the spatial...

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Publicado no:Immunity
Main Authors: Lee, Mark S., Glassman, Caleb R., Deshpande, Neha R., Badgandi, Hemant B., Parrish, Heather L., Uttamapinant, Chayasith, Stawski, Philipp S., Ting, Alice Y., Kuhns, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545397/
https://ncbi.nlm.nih.gov/pubmed/26231119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.018
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