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A mechanical switch couples T cell receptor triggering to the cytoplasmic juxtamembrane regions of CD3ζζ
The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across the cell membrane for conversion to chemical signals remains unresolved. We hypothesized that TCR engagement triggers a change in the spatial...
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| Publicat a: | Immunity |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545397/ https://ncbi.nlm.nih.gov/pubmed/26231119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.018 |
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