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Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4(+) T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501121/ https://ncbi.nlm.nih.gov/pubmed/26173205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05949 |
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