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Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice

T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4(+) T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Deshpande, Neha R, Parrish, Heather L, Kuhns, Michael S
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501121/
https://ncbi.nlm.nih.gov/pubmed/26173205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05949
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