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The late endosome and its lipid BMP act as gateways for the efficient cytosolic access of the delivery agent dfTAT and its macromolecular cargos

Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and without toxicity. Herein, we report on the mechanism of endosomal escape of this cell-penetr...

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Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Erazo-Oliveras, Alfredo, Najjar, Kristina, Truong, Dat, Wang, Ting-Yi, Brock, Dakota J., Prater, Austin R., Pellois, Jean-Philippe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874899/
https://ncbi.nlm.nih.gov/pubmed/27161484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.03.016
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