The late endosome and its lipid BMP act as gateways for the efficient cytosolic access of the delivery agent dfTAT and its macromolecular cargos

Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and without toxicity. Herein, we report on the mechanism of endosomal escape of this cell-penetr...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Erazo-Oliveras, Alfredo, Najjar, Kristina, Truong, Dat, Wang, Ting-Yi, Brock, Dakota J., Prater, Austin R., Pellois, Jean-Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874899/
https://ncbi.nlm.nih.gov/pubmed/27161484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.03.016
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