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Efficient Delivery of Macromolecules into Human Cells by Improving the Endosomal Escape Activity of Cell-Penetrating Peptides: Lessons Learned from dfTAT and its Analogs

Cell-penetrating peptides (CPPs) are typically prone to endocytic uptake into human cells. However, they are often inefficient at escaping from endosomes, which limits their ability to deliver cargos into cells. This review highlights the efforts that our laboratory has devoted toward developing CPP...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Allen, Jason K., Brock, Dakota J., Kondow-McConaghy, Helena M., Pellois, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165022/
https://ncbi.nlm.nih.gov/pubmed/29997347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom8030050
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