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Efficient Delivery of Macromolecules into Human Cells by Improving the Endosomal Escape Activity of Cell-Penetrating Peptides: Lessons Learned from dfTAT and its Analogs

Cell-penetrating peptides (CPPs) are typically prone to endocytic uptake into human cells. However, they are often inefficient at escaping from endosomes, which limits their ability to deliver cargos into cells. This review highlights the efforts that our laboratory has devoted toward developing CPP...

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發表在:Biomolecules
Main Authors: Allen, Jason K., Brock, Dakota J., Kondow-McConaghy, Helena M., Pellois, Jean-Philippe
格式: Artigo
語言:Inglês
出版: MDPI 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165022/
https://ncbi.nlm.nih.gov/pubmed/29997347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom8030050
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