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Mechanism of cell penetration by permeabilization of late endosomes: interplay between a multivalent TAT Peptide and Bis(monoacylglycerol)phosphate

Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes the improvement of delivery agents. Herein, we in...

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Détails bibliographiques
Publié dans:Cell Chem Biol
Auteurs principaux: Brock, Dakota J., Kondow-McConaghy, Helena, Allen, Jason, Brkljača, Zlatko, Kustigian, Lauren, Jiang, Mengqiu, Zhang, Junjie, Rye, Hays, Vazdar, Mario, Pellois, Jean-Philippe
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572721/
https://ncbi.nlm.nih.gov/pubmed/32783962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.07.015
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