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Mechanism of cell penetration by permeabilization of late endosomes: interplay between a multivalent TAT Peptide and Bis(monoacylglycerol)phosphate

Many cellular delivery reagents enter the cytosolic space of cells by escaping the lumen of endocytic organelles and, more specifically, late endosomes. The mechanisms involved in endosomal membrane permeation remain largely unresolved, which impedes the improvement of delivery agents. Herein, we in...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Brock, Dakota J., Kondow-McConaghy, Helena, Allen, Jason, Brkljača, Zlatko, Kustigian, Lauren, Jiang, Mengqiu, Zhang, Junjie, Rye, Hays, Vazdar, Mario, Pellois, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572721/
https://ncbi.nlm.nih.gov/pubmed/32783962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.07.015
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