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The late endosome and its lipid BMP act as gateways for the efficient cytosolic access of the delivery agent dfTAT and its macromolecular cargos
Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and without toxicity. Herein, we report on the mechanism of endosomal escape of this cell-penetr...
Shranjeno v:
| izdano v: | Cell Chem Biol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874899/ https://ncbi.nlm.nih.gov/pubmed/27161484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.03.016 |
| Oznake: |
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