Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucos...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nat Commun
المؤلفون الرئيسيون: Kaushik, Akash K., Shojaie, Ali, Panzitt, Katrin, Sonavane, Rajni, Venghatakrishnan, Harene, Manikkam, Mohan, Zaslavsky, Alexander, Putluri, Vasanta, Vasu, Vihas T., Zhang, Yiqing, Khan, Ayesha S., Lloyd, Stacy, Szafran, Adam T., Dasgupta, Subhamoy, Bader, David A., Stossi, Fabio, Li, Hangwen, Samanta, Susmita, Cao, Xuhong, Tsouko, Efrosini, Huang, Shixia, Frigo, Daniel E., Chan, Lawrence, Edwards, Dean P., Kaipparettu, Benny A., Mitsiades, Nicholas, Weigel, Nancy L., Mancini, Michael, McGuire, Sean E., Mehra, Rohit, Ittmann, Michael M., Chinnaiyan, Arul M., Putluri, Nagireddy, Palapattu, Ganesh S., Michailidis, George, Sreekumar, Arun
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group 2016
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874037/
https://ncbi.nlm.nih.gov/pubmed/27194471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11612
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