Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucos...

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Publicado no:Nat Commun
Main Authors: Kaushik, Akash K., Shojaie, Ali, Panzitt, Katrin, Sonavane, Rajni, Venghatakrishnan, Harene, Manikkam, Mohan, Zaslavsky, Alexander, Putluri, Vasanta, Vasu, Vihas T., Zhang, Yiqing, Khan, Ayesha S., Lloyd, Stacy, Szafran, Adam T., Dasgupta, Subhamoy, Bader, David A., Stossi, Fabio, Li, Hangwen, Samanta, Susmita, Cao, Xuhong, Tsouko, Efrosini, Huang, Shixia, Frigo, Daniel E., Chan, Lawrence, Edwards, Dean P., Kaipparettu, Benny A., Mitsiades, Nicholas, Weigel, Nancy L., Mancini, Michael, McGuire, Sean E., Mehra, Rohit, Ittmann, Michael M., Chinnaiyan, Arul M., Putluri, Nagireddy, Palapattu, Ganesh S., Michailidis, George, Sreekumar, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874037/
https://ncbi.nlm.nih.gov/pubmed/27194471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11612
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