Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer

Efforts to induce the differentiation of cancer stem cells through treatment with all-trans retinoic acid (ATRA) have yielded limited success, partially due to the epigenetic silencing of the retinoic acid receptor (RAR)-β. The histone deacetylase inhibitor, entinostat, is emerging as a promising an...

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Vydáno v:Cancer Res
Hlavní autoři: Merino, Vanessa F., Nguyen, Nguyen, Jin, Kideok, Sadik, Helen, Cho, Soonweng, Korangath, Preethi, Han, Liangfeng, Foster, Yolanda M. N., Zhou, Xian C., Zhang, Zhe, Connolly, Roisin M., Stearns, Vered, Ali, Syed Z., Adams, Christina, Chen, Qian, Pan, Duojia, Huso, David L., Ordentlich, Peter, Brodie, Angela, Sukumar, Saraswati
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873448/
https://ncbi.nlm.nih.gov/pubmed/26787836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1619
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