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Heparanase 2 attenuates head and neck tumor vascularity and growth

The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis. Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains t...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Res
Hauptverfasser: Gross-Cohen, Miriam, Feld, Sari, Doweck, Ilana, Neufeld, Gera, Hasson, Peleg, Arvatz, Gil, Barash, Uri, Naroditsky, Inna, Ilan, Neta, Vlodavsky, Israel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873389/
https://ncbi.nlm.nih.gov/pubmed/27013193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1975
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