Heparanase 2 attenuates head and neck tumor vascularity and growth

The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis. Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains t...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Gross-Cohen, Miriam, Feld, Sari, Doweck, Ilana, Neufeld, Gera, Hasson, Peleg, Arvatz, Gil, Barash, Uri, Naroditsky, Inna, Ilan, Neta, Vlodavsky, Israel
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873389/
https://ncbi.nlm.nih.gov/pubmed/27013193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1975
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