Heparanase 2 attenuates head and neck tumor vascularity and growth

The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has been implicated strongly in tumor metastasis and angiogenesis. Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains t...

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Bibliografische gegevens
Gepubliceerd in:Cancer Res
Hoofdauteurs: Gross-Cohen, Miriam, Feld, Sari, Doweck, Ilana, Neufeld, Gera, Hasson, Peleg, Arvatz, Gil, Barash, Uri, Naroditsky, Inna, Ilan, Neta, Vlodavsky, Israel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873389/
https://ncbi.nlm.nih.gov/pubmed/27013193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1975
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