Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody

T5 is a novel splice variant of heparanase, an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains at a limited number of sites. T5 splice variant is endowed with pro-tumorigenic properties, enhancing cell proliferation, anchorage independent growth and tumor xenograft development...

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Detalhes bibliográficos
Main Authors: Barash, Uri, Arvatz, Gil, Farfara, Roy, Naroditsky, Inna, Doweck, Ilana, Feld, Sari, Ben-Izhak, Ofer, Ilan, Neta, Nativ, Ofer, Vlodavsky, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520799/
https://ncbi.nlm.nih.gov/pubmed/23251556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051494
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