Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor

The Glucagon-like peptide-1 receptor (GLP-1R) is a member of the class B G protein-coupled receptor (GPCR) family and a well-established target for the treatment of type 2 diabetes. The N-terminal extracellular domain (ECD) of GLP-1R is important for GLP-1 binding and the crystal structure of the GL...

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Udgivet i:Sci Rep
Main Authors: Hennen, Stephanie, Kodra, János T., Soroka, Vladyslav, Krogh, Berit O., Wu, Xiaoai, Kaastrup, Peter, Ørskov, Cathrine, Rønn, Sif G., Schluckebier, Gerd, Barbateskovic, Silvia, Gandhi, Prafull S., Reedtz-Runge, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872540/
https://ncbi.nlm.nih.gov/pubmed/27196125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26236
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