Conformational states of the full-length glucagon receptor

Class B G protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones. Using a hybrid structural biology approach together with the ECD and 7TM domain crystal structures of the glucagon receptor...

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Udgivet i:Nat Commun
Main Authors: Yang, Linlin, Yang, Dehua, de Graaf, Chris, Moeller, Arne, West, Graham M., Dharmarajan, Venkatasubramanian, Wang, Chong, Siu, Fai Y., Song, Gaojie, Reedtz-Runge, Steffen, Pascal, Bruce D., Wu, Beili, Potter, Clinton S., Zhou, Hu, Griffin, Patrick R., Carragher, Bridget, Yang, Huaiyu, Wang, Ming-Wei, Stevens, Raymond C., Jiang, Hualiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532856/
https://ncbi.nlm.nih.gov/pubmed/26227798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8859
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