Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis

Lysophosphatidic acid (LPA) is an important mediator of pulmonary fibrosis. In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but alternative enzymatic pathways also exist for LPA production. We examined the role of autotax...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Black, Katharine E., Berdyshev, Evgeny, Bain, Gretchen, Castelino, Flavia V., Shea, Barry S., Probst, Clemens K., Fontaine, Benjamin A., Bronova, Irina, Goulet, Lance, Lagares, David, Ahluwalia, Neil, Knipe, Rachel S., Natarajan, Viswanathan, Tager, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871797/
https://ncbi.nlm.nih.gov/pubmed/27006447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500197R
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