Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis

Lysophosphatidic acid (LPA) is an important mediator of pulmonary fibrosis. In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but alternative enzymatic pathways also exist for LPA production. We examined the role of autotax...

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Detalles Bibliográficos
Publicado en:FASEB J
Main Authors: Black, Katharine E., Berdyshev, Evgeny, Bain, Gretchen, Castelino, Flavia V., Shea, Barry S., Probst, Clemens K., Fontaine, Benjamin A., Bronova, Irina, Goulet, Lance, Lagares, David, Ahluwalia, Neil, Knipe, Rachel S., Natarajan, Viswanathan, Tager, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871797/
https://ncbi.nlm.nih.gov/pubmed/27006447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500197R
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