Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of...

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Main Authors: Park, Gye Young, Lee, Yong Gyu, Berdyshev, Evgeny, Nyenhuis, Sharmilee, Du, Jian, Fu, Panfeng, Gorshkova, Irina A., Li, Yongchao, Chung, Sangwoon, Karpurapu, Manjula, Deng, Jing, Ranjan, Ravi, Xiao, Lei, Jaffe, H. Ari, Corbridge, Susan J., Kelly, Elizabeth A. B., Jarjour, Nizar N., Chun, Jerold, Prestwich, Glenn D., Kaffe, Eleanna, Ninou, Ioanna, Aidinis, Vassilis, Morris, Andrew J., Smyth, Susan S., Ackerman, Steven J., Natarajan, Viswanathan, Christman, John W.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826286/
https://ncbi.nlm.nih.gov/pubmed/24050723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1014OC
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