Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of...

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Autors principals: Park, Gye Young, Lee, Yong Gyu, Berdyshev, Evgeny, Nyenhuis, Sharmilee, Du, Jian, Fu, Panfeng, Gorshkova, Irina A., Li, Yongchao, Chung, Sangwoon, Karpurapu, Manjula, Deng, Jing, Ranjan, Ravi, Xiao, Lei, Jaffe, H. Ari, Corbridge, Susan J., Kelly, Elizabeth A. B., Jarjour, Nizar N., Chun, Jerold, Prestwich, Glenn D., Kaffe, Eleanna, Ninou, Ioanna, Aidinis, Vassilis, Morris, Andrew J., Smyth, Susan S., Ackerman, Steven J., Natarajan, Viswanathan, Christman, John W.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826286/
https://ncbi.nlm.nih.gov/pubmed/24050723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1014OC
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