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Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of...

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Main Authors: Park, Gye Young, Lee, Yong Gyu, Berdyshev, Evgeny, Nyenhuis, Sharmilee, Du, Jian, Fu, Panfeng, Gorshkova, Irina A., Li, Yongchao, Chung, Sangwoon, Karpurapu, Manjula, Deng, Jing, Ranjan, Ravi, Xiao, Lei, Jaffe, H. Ari, Corbridge, Susan J., Kelly, Elizabeth A. B., Jarjour, Nizar N., Chun, Jerold, Prestwich, Glenn D., Kaffe, Eleanna, Ninou, Ioanna, Aidinis, Vassilis, Morris, Andrew J., Smyth, Susan S., Ackerman, Steven J., Natarajan, Viswanathan, Christman, John W.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826286/
https://ncbi.nlm.nih.gov/pubmed/24050723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1014OC
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