Lysophosphatidic acid signaling through its receptor initiates pro-fibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth fa...

Por Sakai, Norihiko, Chun, Jerold, Duffield, Jeremy S., Lagares, David, Wada, Takashi, Luster, Andrew D., Tager, Andrew M.
Publicado no Kidney Int (2016)

Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability

Por Rodríguez-Pascual, Fernando, Redondo-Horcajo, Mariano, Magán-Marchal, Noemi, Lagares, David, Martínez-Ruiz, Antonio, Kleinert, Hartmut, Lamas, Santiago
Publicado em 2008

LOXL4 Is Induced by Transforming Growth Factor β1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

Por Busnadiego, Oscar, González-Santamaría, José, Lagares, David, Guinea-Viniegra, Juan, Pichol-Thievend, Cathy, Muller, Laurent, Rodríguez-Pascual, Fernando
Publicado em 2013

Fibrogenic Lung Injury Induces Non–Cell-Autonomous Fibroblast Invasion

Por Ahluwalia, Neil, Grasberger, Paula E., Mugo, Brian M., Feghali-Bostwick, Carol, Pardo, Annie, Selman, Moisés, Lagares, David, Tager, Andrew M.
Publicado no Am J Respir Cell Mol Biol (2016)

A Pathogenetic Role for Endothelin-1 in Peritoneal Dialysis-Associated Fibrosis

Por Busnadiego, Oscar, Loureiro-Álvarez, Jesús, Sandoval, Pilar, Lagares, David, Dotor, Javier, Pérez-Lozano, María Luisa, López-Armada, María J., Lamas, Santiago, López-Cabrera, Manuel, Rodríguez-Pascual, Fernando
Publicado no J Am Soc Nephrol (2015)

Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis

Por Black, Katharine E., Berdyshev, Evgeny, Bain, Gretchen, Castelino, Flavia V., Shea, Barry S., Probst, Clemens K., Fontaine, Benjamin A., Bronova, Irina, Goulet, Lance, Lagares, David, Ahluwalia, Neil, Knipe, Rachel S., Natarajan, Viswanathan, Tager, Andrew M.
Publicado no FASEB J (2016)

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization

Por Funke, Manuela, Knudsen, Lars, Lagares, David, Ebener, Simone, Probst, Clemens K., Fontaine, Benjamin A., Franklin, Alicia, Kellner, Manuela, Kühnel, Mark, Matthieu, Stephanie, Grothausmann, Roman, Chun, Jerold, Roberts, Jesse D., Ochs, Matthias, Tager, Andrew M.
Publicado no Am J Respir Cell Mol Biol (2016)

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Por Lagares, David, Busnadiego, Oscar, García-Fernández, Rosa Ana, Kapoor, Mohit, Liu, Shangxi, Carter, David E., Abraham, David, Shi-Wen, Xu, Carreira, Patricia, Fontaine T, Benjamin A, Shea, Barry S, Tager, Andrew M, Leask, Andrew, Lamas, Santiago, Rodríguez-Pascual, Fernando
Publicado em 2012

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Por Liu, Fei, Lagares, David, Choi, Kyoung Moo, Stopfer, Lauren, Marinković, Aleksandar, Vrbanac, Vladimir, Probst, Clemens K., Hiemer, Samantha E., Sisson, Thomas H., Horowitz, Jeffrey C., Rosas, Ivan O., Fredenburgh, Laura E., Feghali-Bostwick, Carol, Varelas, Xaralabos, Tager, Andrew M., Tschumperlin, Daniel J.
Publicado no Am J Physiol Lung Cell Mol Physiol (2014)

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Por Vasheghani, Faezeh, Zhang, Yue, Li, Ying-Hua, Blati, Meryem, Fahmi, Hassan, Lussier, Bertrand, Roughley, Peter, Lagares, David, Endisha, Helal, Saffar, Bahareh, Lajeunesse, Daniel, Marshall, Wayne K, Rampersaud, Y Raja, Mahomed, Nizar N, Gandhi, Rajiv, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Kapoor, Mohit
Publicado no Ann Rheum Dis (2015)

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

Por Lagares, David, Ghassemi-Kakroodi, Parisa, Tremblay, Caroline, Santos, Alba, Probst, Clemens K., Franklin, Alicia, Santos, Daniela M., Grasberger, Paula, Ahluwalia, Neil, Montesi, Sydney B., Shea, Barry S., Black, Katharine E., Knipe, Rachel, Blati, Meryem, Baron, Murray, Wu, Brian, Fahmi, Hassan, Gandhi, Rajiv, Pardo, Annie, Selman, Moisés, Wu, Jiangping, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Tager, Andrew M., Kapoor, Mohit
Publicado no Nat Med (2017)