PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

OBJECTIVES: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created inducible cartilage-specific PPARγ knockout (KO) mice and subjected these mice...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Vasheghani, Faezeh, Zhang, Yue, Li, Ying-Hua, Blati, Meryem, Fahmi, Hassan, Lussier, Bertrand, Roughley, Peter, Lagares, David, Endisha, Helal, Saffar, Bahareh, Lajeunesse, Daniel, Marshall, Wayne K, Rampersaud, Y Raja, Mahomed, Nizar N, Gandhi, Rajiv, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Kapoor, Mohit
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345902/
https://ncbi.nlm.nih.gov/pubmed/25573665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205743
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