High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Metabolic changes induced by high fat diet (HFD) that contribute to osteoarthritis (OA) are poorly understood. We investigated longitudinal changes to metabolites and their contribution to OA pathogenesis in response to HFD. HFD-fed mice exhibited acceleration of spontaneous age-related and surgical...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Datta, Poulami, Zhang, Yue, Parousis, Alexa, Sharma, Anirudh, Rossomacha, Evgeny, Endisha, Helal, Wu, Brian, Kacprzak, Izabela, Mahomed, Nizar N., Gandhi, Rajiv, Rockel, Jason S., Kapoor, Mohit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557929/
https://ncbi.nlm.nih.gov/pubmed/28811491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07963-6
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