Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and a...

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Detalhes bibliográficos
Publicado no:JCI Insight
Principais autores: Lietman, Caressa, Wu, Brian, Lechner, Sarah, Shinar, Andrew, Sehgal, Madhur, Rossomacha, Evgeny, Datta, Poulami, Sharma, Anirudh, Gandhi, Rajiv, Kapoor, Mohit, Young, Pampee P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821202/
https://ncbi.nlm.nih.gov/pubmed/29415892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96308
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