Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and a...

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Vydáno v:JCI Insight
Hlavní autoři: Lietman, Caressa, Wu, Brian, Lechner, Sarah, Shinar, Andrew, Sehgal, Madhur, Rossomacha, Evgeny, Datta, Poulami, Sharma, Anirudh, Gandhi, Rajiv, Kapoor, Mohit, Young, Pampee P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821202/
https://ncbi.nlm.nih.gov/pubmed/29415892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96308
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