Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and a...

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發表在:JCI Insight
Main Authors: Lietman, Caressa, Wu, Brian, Lechner, Sarah, Shinar, Andrew, Sehgal, Madhur, Rossomacha, Evgeny, Datta, Poulami, Sharma, Anirudh, Gandhi, Rajiv, Kapoor, Mohit, Young, Pampee P.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821202/
https://ncbi.nlm.nih.gov/pubmed/29415892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96308
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