High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Metabolic changes induced by high fat diet (HFD) that contribute to osteoarthritis (OA) are poorly understood. We investigated longitudinal changes to metabolites and their contribution to OA pathogenesis in response to HFD. HFD-fed mice exhibited acceleration of spontaneous age-related and surgical...

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Udgivet i:Sci Rep
Main Authors: Datta, Poulami, Zhang, Yue, Parousis, Alexa, Sharma, Anirudh, Rossomacha, Evgeny, Endisha, Helal, Wu, Brian, Kacprzak, Izabela, Mahomed, Nizar N., Gandhi, Rajiv, Rockel, Jason S., Kapoor, Mohit
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557929/
https://ncbi.nlm.nih.gov/pubmed/28811491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07963-6
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