High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Metabolic changes induced by high fat diet (HFD) that contribute to osteoarthritis (OA) are poorly understood. We investigated longitudinal changes to metabolites and their contribution to OA pathogenesis in response to HFD. HFD-fed mice exhibited acceleration of spontaneous age-related and surgical...

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Vydáno v:Sci Rep
Hlavní autoři: Datta, Poulami, Zhang, Yue, Parousis, Alexa, Sharma, Anirudh, Rossomacha, Evgeny, Endisha, Helal, Wu, Brian, Kacprzak, Izabela, Mahomed, Nizar N., Gandhi, Rajiv, Rockel, Jason S., Kapoor, Mohit
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557929/
https://ncbi.nlm.nih.gov/pubmed/28811491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07963-6
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