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Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH

Fetal hemoglobin is a major genetic modifier of the phenotypic heterogeneity in patients with sickle cell disease and certain β-thalassemias. Normal levels of fetal hemoglobin postnatally are approximately 1% of total hemoglobin. Patients who have hereditary persistence of fetal hemoglobin, characte...

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Bibliografski detalji
Izdano u:Exp Biol Med (Maywood)
Glavni autori: Braghini, Carolina A, Costa, Flavia C, Fedosyuk, Halyna, Neades, Renee Y, Novikova, Lesya V, Parker, Matthew P, Winefield, Robert D, Peterson, Kenneth R
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871743/
https://ncbi.nlm.nih.gov/pubmed/26946532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370216636724
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