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Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator

Sickle cell disease (SCD) and β-thalassemia patients are phenotypically normal if they carry compensatory hereditary persistence of fetal hemoglobin (HPFH) mutations that result in increased levels of fetal hemoglobin (HbF, γ-globin chains) in adulthood. Thus, research has focused on manipulating th...

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Detalhes bibliográficos
Main Authors: Flávia C. Costa, Halyna Fedosyuk, Renee Neades, Johana Bravo de Los Rios, Carlos F. Barbas, Kenneth R. Peterson
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2012-01-01
Colecção:Anemia
Acesso em linha:http://dx.doi.org/10.1155/2012/507894
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