Dose escalation with over-dose and under-dose controls in Phase I/II clinical trials

To save valuable time and resources in new drug development, Phase I/II clinical trials with toxicity control and drug efficacy as dual primary endpoints have become increasingly popular. Escalation with over-dose control (the EWOC) is a Bayesian adaptive Phase I clinical trial design that can accur...

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Pubblicato in:Contemp Clin Trials
Autori principali: Chen, Zhengjia, Yuan, Ying, Li, Zheng, Kutner, Michael, Owonikoko, Taofeek, Curran, Walter J., Khuri, Fadlo, Kowalski, Jeanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871606/
https://ncbi.nlm.nih.gov/pubmed/26012358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2015.05.014
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