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Dose escalation with over-dose and under-dose controls in Phase I/II clinical trials
To save valuable time and resources in new drug development, Phase I/II clinical trials with toxicity control and drug efficacy as dual primary endpoints have become increasingly popular. Escalation with over-dose control (the EWOC) is a Bayesian adaptive Phase I clinical trial design that can accur...
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| Vydáno v: | Contemp Clin Trials |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871606/ https://ncbi.nlm.nih.gov/pubmed/26012358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2015.05.014 |
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