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Dose Escalation with Overdose Control using a Quasi-Continuous Toxicity Score in Cancer Phase I Clinical Trials

Escalation with overdose control (EWOC) is a Bayesian adaptive design for selecting dose levels in cancer Phase I clinical trials while controlling the posterior probability of exceeding the maximum tolerated dose (MTD). EWOC has been used by clinicians to design many cancer Phase I clinical trials,...

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Bibliografische gegevens
Hoofdauteurs: Chen, Zhengjia, Tighiouart, Mourad, Kowalski, Jeanne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046335/
https://ncbi.nlm.nih.gov/pubmed/22561391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2012.04.007
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